Suppression of Ribosome Biogenesis by Targeting WD Repeat Domain 12 (WDR12) Inhibits Glioma Stem-Like Cell Growth

Glioma stem-like cells (GSCs) are a subset of tumor cells Quickstrikes that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor.Ribosome biogenesis is an essential cellular process to maintain cell growth, but its regulatory mechanism in GSCs remains largely unknown.Here, we show tha

read more


Raspberry ketone diet supplement reduces attraction of sterile male Queensland fruit fly to cuelure by altering expression of chemoreceptor genes

Abstract Sterile male Queensland fruit fly, Bactrocera tryoni (Froggatt), fed as immature adults on the plant compound raspberry ketone (RK), show a reduced attraction to cuelure, a synthetic Storage analogue of RK used as an attractant in Male Annihilation Technique.We hypothesized the reduced attraction of RK-fed adult males to cuelure may be a c

read more